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Izon Science Support Centre

qNano

qNano

Information and support for using the qNano TRPS measurement system.

Troubleshooting: System Setup

When should the low gain stage be used?

The signal trace appears as a yellow band or upward spikes. What does this mean?

Baseline current keeps railing when working with larger nanopores (NP1000 and larger)

The centre of the lower fluid cell looks grey. Is that normal?

How can I improve my signal-to-noise ratio?

The baseline current is fluctuating/drifting. How do I stabilise the baseline current?

When and how should I clean the lower fluid cell?

I have followed the system setup steps but the baseline current is still ~0 nA. Why is there no current flow?

The software will not allow the Custom Planner or Classic Capture tabs to run. How do I fix this?

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Troubleshooting: TRPS Measurements

How do I increase the particle rate?

Particle diameter is not as expected. Why is this?

Baseline current drops to 0 nA after changing sample in the upper fluid cell. What does this mean?

I've put my sample in the upper fluid cell but I can't see any blockades. What should I do?

Baseline current cannot be recovered between measurements.

What are the recommended qNano settings for zeta potential measurements compared with conventional size and concentration measurements?

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Troubleshooting: Blockages and Bubbles

The rate plot does not display a constant gradient. Why is this important and what can be done to rectify the issue?

Troubleshooting: Pressure Module

There is no change in pressure as I move the plunger. Is the VPM leaking?

Is my Pressure Reading Module (PM2) working?

Instrument Maintenance

How do I disassemble and clean the fluid cell?

I'm working with virus particles. How do I decontaminate the instrument?

Is my VPM functioning correctly?

The stretcher unit doesn't move when the stretch adjustment handle is rotated.

How often should the instrument be serviced?

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Installation and System Setup

How do I apply vacuum with the VPM?

How do I apply pressure with the VPM?

The holding stage doesn't move. What can I do?

How do I set up my qNano system?

I've just received my instrument. How do I get started?

Which way should I orientate the nanopore on the holding stage?

How do I install a Pressure Reading Module on the qNano?

What are the required computer specifications?

What additional pieces of lab equipment and/or consumables are required?

qNano Quick Start Guide

Overview: qNano Training Programme

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Product Overview and Reference Material

qNano User Manual

Video: Maintaining a stable baseline current

Video: Sample Changeover

Components Overview: Variable Pressure Module (VPM)

How do I perform zeta potential measurements on the qNano?

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