The baseline current is fluctuating/drifting. How do I stabilise the baseline current?

The baseline current should be stable during the experiment. If the baseline current is rapidly fluctuating or drifting, this needs to be corrected. Investigate the possible causes for a drifting baseline shown below:

While the baseline current should be stable during recording, small baseline current drifts can often be observed, especially as the day progresses. This is due to a slight changes in the nanopore (TPU absorbs low levels of water) as well as fluctuations in room temperature.