Does the pH value of electrolyte matter when completing measurements on the qNano system?

Yes. The qNano system components and consumables which includes fluid cells, calibration particles, and nanopores are compatible with electrolytes within a pH range of 4-10. Ideally electrolytes with a pH of 7-7.4 (physiological conditions) are used. If the electrolyte that is used is of a different pH, please contact Izon to enquire about material compatibility testing. 

More importantly, Izon calibration particles are made of carboxylated polystyrene which have a pKa of approximately 5. These calibration particles are stable in electrolyte with pH of 7-7.4. If the electrolyte solution that is used has a pH of 5.5 (for example), this will cause aggregation of the calibration particles as they will carry minimal charge at pH 5.5.